Transpeptidases, such as the sortases responsible for anchoring factors like protein A to the staphylococcal peptidoglycan, are being studied in hopes of developing new antibiotics to target MRSA infections. aureus are capable of producing staphyloxanthin — a golden-coloured carotenoid pigment.
This pigment acts as a virulence factor, primarily by being a bacterial antioxidant which helps the microbe evade the reactive oxygen species which the host immune system uses to kill pathogens. aureus modified to lack staphyloxanthin are less likely to survive incubation with an oxidizing chemical, such as hydrogen peroxide, than pigmented strains.
particularly when skin or mucosal barriers have been breached. aureus infections can spread through contact with pus from an infected wound, skin-to-skin contact with an infected person, and contact with objects used by an infected person such as towels, sheets, clothing, or athletic equipment. This can manifest in various ways, including small benign boils, folliculitis, impetigo, cellulitis, and more severe, invasive soft-tissue infections. aureus is extremely prevalent in persons with atopic dermatitis.
Joint replacements put a person at particular risk of septic arthritis, staphylococcal endocarditis (infection of the heart valves), and pneumonia. It is mostly found in fertile, active places, including the armpits, hair, and scalp.
Protein A, an Ig G-binding protein, binds to the Fc region of an antibody.
In mice, the pigmented strains cause lingering abscesses when inoculated into wounds, whereas wounds infected with the unpigmented strains quickly heal.
The emergence of antibiotic-resistant strains of S. aureus (MRSA) is a worldwide problem in clinical medicine. Complete separation of the daughter cells is mediated by S.
Despite much research and development there is no approved vaccine for S. impetigo, boils, cellulitis, folliculitis, carbuncles, scalded skin syndrome, and abscesses, to life-threatening diseases such as pneumonia, meningitis, osteomyelitis, endocarditis, toxic shock syndrome, bacteremia, and sepsis. aureus autolysin, and in its absence or targeted inhibition, the daughter cells remain attached to one another and appear as clusters.) to water and oxygen.
The bicomponent toxin PVL is associated with severe necrotizing pneumonia in children.
Further investigation of ica R m RNA (m RNA coding for the repressor of the main expolysaccharidic compound of the bacteria biofilm matrix) demonstrated that the 3'UTR binding to the 5' UTR can interfere with the translation initiation complex and generate a double stranded substrate for RNase III.