She was urged to participate in the "Miss Chelyabinsk 2004" beauty contest and she won.In 2007, she replaced Ana Beatriz Barros as the face of Intimissimi, and in the same year debuted in the annual Sports Illustrated Swimsuit Issue.On 14 February 2011 episode of the Late Show with David Letterman, it was revealed via Billboard that Shayk was the covermodel for the 2011 Sports Illustrated Swimsuit Issue.
She has appeared in advertising campaigns for Alberta Ferretti, Givenchy, La Perla, Roberto Cavalli, La Senza, Morellato, bebe, Lord & Taylor, Lacoste, Armani Exchange, Guess, Saks Fifth Avenue, Victoria's Secret, and Avon.
's latest girlfriend, whom he started dating in 2010. After kicking off her modeling career in Europe when she was only 19 years old, she didn't get immediately popular as many would have thought.
Her first experience abroad was a bit hard, as she could barely speak any English at all and therefore ended up struggling to fit in.
The same month she did the runway of Jeremy Scott during the New York fashion week.
In March 2013 she did the runway of Givenchy during the Paris fashion week.