Inizia a lavorare in vari spot pubblicitari e in serie televisive, fino a quando ottiene il ruolo della dottoressa Anna Del Amico in E. - Medici in prima linea: con questo ruolo ottiene una certa notorietà che le permette di diventare un'attrice cinematografica e lavorare in film come Payback - La rivincita di Porter, Le ragazze del Coyote Ugly, The Cooler, Secret Window.Recita in Secret Window di David Koepp e in A History of Violence di David Cronenberg; successivamente lavora in Thank You for Smoking e in World Trade Center di Oliver Stone.She is perhaps best known to American audiences for her role as Persephone in the 2003 science-fiction films The Matrix Reloaded and The Matrix Revolutions.
In the documentary movie The Big Question, about the film The Passion of the Christ, she stated: "I am an agnostic, even though I respect and am interested in all religions.
I mean, I've never loved someone so much and I've never been so afraid in my life.
And the truth is I would kill someone, whoever tried to hurt him.
"Two of my favorite beings on this planet @officialmariabello and @claremunn at the #HRC gala," Allan-Blitz captioned a pic in March 2015. On the Set of Coyote Ugly With Maria Bello and Piper Perabo Two of my favorite beings on this planet @officialmariabello & @claremunn at the #HRC gala Thank you @chadhuntergriffin standing for all human rights #Loveis Love coming soon A post shared by Elijah Allan-Blitz (@elijah_a.b) on MORE: Cara Delevingne on Being Bisexual -- It's 'Not a Phase'When ET spoke to the actress earlier this month at the Human Rights Campaign Los Angeles Gala Dinner to honor Nina Jacobson, she was very candid about her sexual preferences. "I think sexuality in general [wasn't] really talked about before, and the millennial generation, this generation, is quite different. There's 52 things you can modify for your sexual preferences.
Love is love."Bello shared a similar sentiment when ET chatted with her in April 2015 about her book.